Nucleosomes represent mechanical and energetic barriers that RNA Polymerase II (Pol II) must overcome during transcription.A high-resolution description of the barrier topography, its modulation by epigenetic modifications, and their effects on Pol II nucleosome crossing dynamics, is still missing.Here, we obtain topographic and transcriptional (Po
Estimating sewage flow rate in Jefferson County, Kentucky, using machine learning for wastewater-based epidemiology applications
Direct measurement of the flow rate in sanitary sewer lines is not always feasible and is an important parameter for the normalization of data used in wastewater-based epidemiology applications.Machine learning to estimate past wastewater influent flow rates supporting public health applications has not been studied.The aim of this study was to ass
Identification of a 251 gene expression signature that can accurately detect M. tuberculosis in patients with and without HIV co-infection.
BackgroundCo-infection with tuberculosis (TB) is the leading cause of death in HIV-infected individuals.However, diagnosis of TB, especially in the presence of an HIV co-infection, can be limiting due to the high inaccuracy associated with the use of conventional diagnostic methods.Here we report a gene signature that can identify a tuberculosis in
Ignition mechanism and chemical reaction of the micro-damage polymer-bonded explosives under different inertial loading conditions
Understanding korpskaft the impact-induced ignition properties and energy release behavior of polymer-bonded explosives (PBXs) is critical for the safety of explosive systems.In this study, a new impact test component was designed using a light gas gun to quantify the ignition mechanism and chemical reaction of micro-damaged PBXs under different in